Sand fly collection field work
VectorNet, 22 June - 04 July 2014, 1 July – 2 September 2015
Bosnia-Herzegovina, Montenegro, Croatia, Serbia, Bulgaria, Macedonia and Kosovo.
Education.
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2021 Post-Doctoral Emergence of Viral Diseases
Aix Marseille University, Marseille, FRANCE Faculty of Medicine, Department of Emergence of Viral Diseases
Research Subject: Emerging infectious vector borne viruses and development of sars-cov-2 serological assays
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2020 Post-Doctoral Unité de Virologie EA7310 Bioscope
Unité de Virologie EA7310 Bioscope, Université de Corse Pasquale Paoli, Corsica, FRANCE
Research Subject: Tick borne viruses and sero neutralisation assay automatisation.
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2017-2019 Post-Doctoral Emergence of Viral Diseases
Aix Marseille University, Marseille, FRANCE Faculty of Medicine, Department of Emergence of Viral Diseases
Research Subject: Developing non-mammalian expression systems with using reverse genetic and re-coding systems in live attenuated Bunyaviruses.
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2014-2017 PhD Emergence of Viral Diseases
Aix Marseille University, Marseille, FRANCE Faculty of Medicine, Department of Emergence of Viral Diseases
Thesis: Emerging Sandfly-borne Phleboviruses in Balkan Countries: Virus isolation, Characterization, Evolution and Seroepidemiology.
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2011-2013 M.Sc Evolutionary Genetics
Hacettepe University, Ankara, TURKEY Enstitute of Science, Department of Evolutionary Biology and Genetics
CGPA: 3.91/4.00Thesis: The Effect of Food Restriction on the Genetic Variances of Development Time and Female Fecundity in Drosophila melanogaster Isolines.
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2008-2011 B.S. Anthropology
Hacettepe University, Ankara, TURKEY Faculty of Social Science, Department of Anthropology
CGPA: 3.33/4.00 -
2006-2011 B.S. Biology
Hacettepe University, Ankara, TURKEY Faculty of Science, Department of Biology
CGPA: 3.19/4.00
Research Experience.
Microbiology Research
Internship Program in Gulhane Military Medical Academy Microbiology Department, Turkey
Medical Biology
Internship Program in Hacettepe University Medical Biology Department, Turkey
Evolutionary Biology
Research student in Hacettepe University, Biology Department, with Dr. Ergi Deniz Ozsoy and Dr. Banu Şebnem Önder, Turkey
Evolutionary Genetics
Intern Research Student in Groningen University Evolutionary Genetics Research Group, with Dr. Corneel Vermeulen, Netherlands
Virus isolation, Characterization, Evolution and Seroepidemiology
Aix Marseille University, Faculty of Medicine, with Dr. Remi Charrel, France
Arboviruses
Aix Marseille University, Faculty of Medicine, with Dr. Remi Charrel, France
Publications.
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47. Elbadry, M.A., Efstathion, C.A., Qualls, W.A., Tagliamonte, M.S., Alam, M.M., Khan, M.S.R., Ryan, S.J., Xue, R.D., Charrel, R.N., Bangonan, L. and Salemi, M., 2023. Diversity and Genetic Reassortment of Keystone Virus in Mosquito Populations in Florida. The American Journal of Tropical Medicine and Hygiene, pp.ajtmh-22.
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46. Benbetka, C., Hachid, A., Benallal, K.E., Khardine, F.A., Ayhan, N., Bouredjoul, N., Boulehbal, W.M., Bellila, D., Khaldi, A. and Charrel, R. Epidemiology, Isolation, and Genetic Characterization of Toscana Virus in Algerian Patients Displaying Neurological Infection, 2016–2018. IJID regions, 7, pp.193-198. 2023.
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45. Laroche, L., Ayhan, N., Charrel, R., Bañuls, A.L. and Prudhomme, J. Persistence of Toscana virus in sugar and blood meals of phlebotomine sand flies: epidemiological and experimental consequences. Scientific Reports, 13(1), p.5608. 2023.
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44. Ayhan, N., Rodríguez-Teijeiro, J.D., López-Roig, M., Vinyoles, D., Ferreres, J.A., Monastiri, A., Charrel, R. and Serra-Cobo, J., 2023. High rates of antibodies against Toscana and Sicilian phleboviruses in common quail Coturnix coturnix birds. Frontiers in Microbiology, 13, p.5056. 2022.
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43. Ortuño, M., Muñoz, C., Spitzová, T., Sumova, P., Iborra, M.A., Pérez‐Cutillas, P., Ayhan, N., Charrel, R.N., Volf, P. and Berriatua, E. Exposure to Phlebotomus perniciosus sandfly vectors is positively associated with Toscana virus and Leishmania infantum infection in human blood donors in Murcia Region, southeast Spain. Transboundary and Emerging Diseases. 2022
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42. Sellali, S., Lafri, I., Hachid, A., Ayhan, N., Benbetka, C., Medrouh, B., Messahel, N.E., Bekara, M.E.A., Lafri, M., Charrel, R.N. and Bitam, I. Presence of the sandfly-borne phlebovirus (Toscana virus) in different bio-geographical regions of Algeria demonstrated by a microneutralisation-based seroprevalence study in owned dogs. Comparative Immunology, Microbiology and Infectious Diseases, 88, p.101861. 2022
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41. Bharucha, T., Gangadharan, B., Kumar, A., Myall, A.C., Ayhan, N., Pastorino, B., Chanthongthip, A., Vongsouvath, M., Mayxay, M., Sengvilaipaseuth, O. and Rattanavong, S. Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection. bioRxiv. 2022
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40. Bharucha, T., Ayhan, N., Pastorino, B., Rattanavong, S., Vongsouvath, M., Mayxay, M., Changthongthip, A., Sengvilaipaseuth, O., Phonemixay, O., Pommier, J.D. and Gorman, C. Immunoglobulin M seroneutralization for improved confirmation of Japanese encephalitis virus infection in a flavivirus-endemic area. Transactions of The Royal Society of Tropical Medicine and Hygiene. 2022.
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39. Cicculli, V., Maitre, A., Ayhan, N., Mondoloni, S., Paoli, J.C., Vial, L., de Lamballerie, X.N., Charrel, R. and Falchi, A. Lack of Evidence for Crimean-Congo Hemorrhagic Fever Virus in Ticks Collected from Animals, Corsica, France. Emerging Infectious Diseases, 28(5), pp.1035-1038. 2022.
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38. Ayhan, N., Hachid, A., Thirion, L., Benallal, K.E., Pezzi, L., Khardine, F.A., Benbetka, C., Benbetka, S., Harrat, Z. and Charrel, R. Detection and Isolation of Sindbis Virus from Field Collected Mosquitoes in Timimoun, Algeria. Viruses, 14(5), p.894. 2022.
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37. Cicculli, V., Ayhan, N., Luciani, L., Pezzi, L., Maitre, A., Decarreaux, D., de Lamballerie, X., Paoli, J.C., Vial, L., Charrel, R. and Falchi, A. Molecular detection of parapoxvirus in Ixodidae ticks collected from cattle in Corsica, France. Veterinary Medicine and Science. 2022.
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36. Ortuño, M., Muñoz, C., Spitzová, T., Sumova, P., Iborra, M.A., Pérez‐Cutillas, P., Ayhan, N., Charrel, R.N., Volf, P. and Berriatua, E., Exposure to Phlebotomus perniciosus sand fly vectors is positively associated with Toscana virus and Leishmania infantum infection in human blood donors in Murcia Region, southeast Spain. Transboundary and Emerging Diseases. 2022.
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35. Ayhan, N., Alten, B., Ivovic, V., Cvetkovikj, A., Stefanovska, J., Martinkovic, F., Piorkowski, G., Moureau, G., Gould, E.A., Pettersson, J.H.O. and de Lamballerie, X., 2021. Field surveys in Croatia and North Macedonia reveal two novel phleboviruses circulating in sandflies. Journal of General Virology, 102(11), p.001674.
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34. Laroche, L., Jourdain, F., Ayhan, N., Bañuls, A.L., Charrel, R. and Prudhomme, J., 2021. Incubation Period for Neuroinvasive Toscana Virus Infections. Emerging infectious diseases, 27(12), pp.3147-3150.
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33. Maia, C., Ayhan, N., Cristóvão, J.M., Pereira, A. and Charrel, R., 2021. Human seroprevalence of Toscana virus and Sicilian phlebovirus in the southwest of Portugal. European Journal of Clinical Microbiology & Infectious Diseases, pp.1-5.
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32. Younes, L., Barré-Cardi, H., Bedjaoui, S., Ayhan, N., Varloud, M., Mediannikov, O., Otranto, D. and Davoust, B., 2021. Dirofilaria immitis and Dirofilaria repens in mosquitoes from Corsica Island, France. Parasites & Vectors, 14(1), pp.1-7.
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31. Ayhan, N., López-Roig, M., Monastiri, A., Charrel, R.N. and Serra-Cobo, J., Seroprevalence of Toscana Virus and Sandfly Fever Sicilian Virus in European Bat Colonies Measured Using a Neutralization Test. Viruses. 2021. 13(1), p.88.
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30. Dvorak, V., Kasap, O.E., Ivovic, V., Mikov, O., Stefanovska, J., Martinkovic, F., Omeragic, J., Pajovic, I., Baymak, D., Oguz, G., Ayhan, N. and Hlavackova, K., 2020. Sand flies (Diptera: Psychodidae) in eight Balkan countries: historical review and region-wide entomological survey. Parasites & vectors, 13(1), pp.1-15.
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29. Capai, L., Ayhan, N., Masse, S., Canarelli, J., Priet, S., Simeoni, M.H., Charrel, R.N., de Lamballerie, X. and Falchi, A. Seroprevalence of SARS-CoV-2 IgG antibodies, in Corsica (France), medRxiv, 2020.
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28. Cicculli, V., DeCarreaux, D., Ayhan, N., Casabianca, F., de Lamballerie, X., Charrel, R. and Falchi, A. Molecular screening of Anaplasmataceae in ticks collected from cattle in Corsica, France. Experimental and Applied Acarology, 81(4), pp.561-574. 2020.
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27. Muñoz, C., Ayhan, N., Ortuño, M., Ortiz, J., Gould, E.A., Maia, C., Berriatua, E., Charrel, R.N., 2020. Experimental Infection of Dogs with Toscana Virus and Sandfly Fever Sicilian Virus to Determine Their Potential as Possible Vertebrate Hosts. Microorganisms, 8(4), 596. 2020.
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26. Morini, S., Calzolari, M., Rossini, G., Pascarelli, N., Porcellini, A., Randi, V., Re, C.M, Albieri, A., Bonilauri, P., Bellini, B., Ayhan, N., Charrel, R., Varani, S. Detection of Specific Antibodies against Toscana Virus among Blood Donors in Northeastern Italy and Correlation with Sand Fly Abundance in 2014. Microorganisms, 8(2), 145.2020.
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25. Ayhan, N., Prudhomme, J., Laroche, L., Bañuls, A. L., Charrel, R. N. Broader Geographical Distribution of Toscana Virus in the Mediterranean Region Suggests the Existence of Larger Varieties of Sand Fly Vectors. Microorganisms, 8(1), 114. 2020
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24. Ayhan, N., and Charrel R. An update on Toscana virus distribution, genetics, medical and diagnostic aspects. Clinical Microbiology and Infection. 2020.
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23. Pereira, A., Ayhan, N., Cristóvão, J. M., Vilhena, H., Martins, Â., Cachola, P., Spitzova, T. Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal. Microorganisms, 7(9), 339. 2019
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22. Masse, S., Ayhan, N., Capai, L., Bosseur, F., de Lamballerie, X., Charrel, R. and Falchi, A. Circulation of Toscana Virus in a Sample Population of Corsica, France. Viruses, 11(9), 817. 2019
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21. Vaselek, S., Dvorak, V., Hlavackova, K., Ayhan, N., Halada, P., Oguz, G., Ivović, V., Ozbel, Y., Charrel, R.N., Alten, B. and Petrić, D. A survey of sand flies (Diptera, Phlebotominae) along recurrent transit routes in Serbia. Acta tropica, 105063. 2019
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20. Bino, S., Velo, E., Kadriaj, P., Kota, M., Moureau, G., Lamballerie, X., Bagramian, A., Charrel, R.N., Ayhan, N. Detection of a Novel Phlebovirus (Drin Virus) from Sand Flies in Albania. Viruses, 11, 469. 2019
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19. Jancarova, M., Bichaud, L., Hlavacova, J., Priet, S., Ayhan, N., Spitzova, T., Volf, P. and Charrel, R.N. Experimental Infection of Sand Flies by Massilia Virus and Viral Transmission by Co-Feeding on Sugar Meal. Viruses, 11(4), 332. 2019
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18. Ayhan, N. and Charrel, R.N. Emergent Sand Fly–Borne Phleboviruses in the Balkan Region. Emerging Infectious Diseases, 24(12), 2324. 2018
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17. Pudar, D., Petrić, D., Allène, X., Alten, B., Ayhan, N., Cvetkovikj, A., Garros, C., Goletić, T., Gunay, F., Hlavackova, K. and Ćupina, A.I. An update of the Culicoides (Diptera: Ceratopogonidae) checklist for the Balkans. Parasites & Vectors, 11(1), 462. 2018
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16. Charrel, R.N., Berenger, J.M., Laroche, M., Ayhan, N., Bitam, I., Delaunay, P. and Parola, P., . Neglected vector-borne bacterial diseases and arboviruses in the Mediterranean area. New Microbes and New Infections, 26, 31-36. 2018
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15. Alkan, C., Moin Vaziri, V., Ayhan, N., Badakhshan, M., Bichaud, L., Rahbarian, N., Javadian E. A., Alten, B., de Lamballerie, X., Charrel, R. N. Isolation and sequencing of Dashli virus, a novel Sicilian-like virus in sandflies from Iran; genetic and phylogenetic evidence for the creation of one novel species within the Phlebovirus genus in the Bunyaviridae family. PLoS Neglected Tropical Diseases, 11(12). 2017
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14. Ayhan, N., Alten, B., Ivovic, V., Martinkovic, F., E Kasap, O., Ozbel, Y., de Lamballerie, X., Charrel, R.N. Co-circulation of two lineages of Toscana virus in Croatia. Frontiers in Public Health, 5, 336. 2017
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13. Vaselek, S., Ayhan, N., Oguz, G., Kasap, O. E., Savić, S., Di Muccio, T.,Gradoni, L., Ozbel Y., Alten, B., Petrić, D. Sand fly and Leishmania spp. survey in Vojvodina (Serbia): first detection of Leishmania infantum DNA in sand flies and the first record of Phlebotomus (Transphlebotomus) mascittii Grassi, 1908. Parasites & Vectors, 10(1), 444. 2017
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12. Ayhan, N., Charrel, R.N. Of Phlebotomines (Sandflies) and Viruses: A Comprehensive Perspective On A Complex Situation. Current Opinion in Insect Science, 22, 117-124. 2017
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11. Ayhan, N., Sherifi, K., Taraku, A., Bërxholi, K., Charrel, R.N. High Rates of Neutralizing Antibodies to Toscana and Sandfly Fever Sicilian Viruses in Livestock, Kosovo. Emerging infectious diseases, 23(6), 989. 2017
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10. Pierro, A., Ficarelli, S., Ayhan, N., Morini, S., Raumer, L., Bartoletti, M., Mastroianni, A., Prati, F., Schivazappa S., Cenni, P., Vocale, C., Rossini, G., Gaibani, P., Sambri, V., Landini M.P. Characterization of antibody response in neuroinvasive infection caused by Toscana virus. Clinical Microbiology and Infection, 23(11), 868-873. 2017
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9. Ayhan, N., Alten, B., Ivovic, V., Dvorak, V., Martinkovic, F., Omeragic, J., Stefanovska, J., Petric, D., Vaselek, S., Baymak, D., Kasap, O.E., Volf, P., Charrel, N.R. Direct evidence for an expanded circulation area of the recently identified Balkan virus (Sandfly fever Naples virus species) in several countries of the Balkan archipelago. Parasites & Vectors. 10(1), 402. 2017
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8. Ayhan, N., Gueler, P., Onder, B.S. Lipocalin gene expression is varied in developmental stages by larval nutritional stress in Drosophila. Turkish Journal of Biology. 41(1), 178-186. 2017
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7. Huemer, H., Prudhomme, J., Amaro, F., Baklouti A., Walder, G., Alten, B., Moutailler, S., Ergunay, K., Charrel, R.N., Ayhan, N. Practical guidelines for studies on sandfly-borne phleboviruses: part II: important points to consider for field work and subsequent virological screening. Vector Borne Zoonotic Diseases. 17(1):81-90. 2016
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6. Ayhan, N., Baklouti A., Prudhomme, J., Walder, G., Amaro, F., Alten, B., Moutailler, S., Ergunay, K., Charrel, R.N., Huemer H. Practical guidelines for studies on sandfly-borne phleboviruses: part I: important points to consider ante field work. Vector Borne Zoonotic Diseases. 17(1): 73-80. 2016
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5. Ayhan, N., Velo, E., de Lamballerie, X., Kota, M., Kadriaj, P., Ozbel, Y., Charrel, R.N., Bino, S. Detection of Leishmania infantum and a novel phlebovirus (Balkan virus) from sand flies in Albania. Vector Borne Zoonotic Diseases. 2016
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4. Alwassouf, S., Maia, C., Ayhan, N., Coimbra, M., Cristovao, J.M., Richet, H., Charrel, R.N. Neutralisation-based seroprevalence of Toscana virus and Sandfly fever Sicilian virus in dogs and cats from Portugal. Journal of General Virology. 97(11). 2016
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3. Ergunay, K., Ayhan, N., Charrel, R.N. Novel and emergent sandfly‐borne phleboviruses in Asia Minor: a systematic review. Reviews in Medical Virology. 2016
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2. Ayhan, N., Guler, P., Onder. B.S. The Effect of Dietary Stress on the Genetic Variances of Life History Traits in Drosophila melanogaster. Journal of Thermal Biology. 2016
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1. Guler, P., Ayhan, N., Koşukcu, C. and Onder, B.S. The effects of larval diet restriction on developmental time, pre-adult survival and wing length in Drosophila melanogaster. Turkish Journal of Zoology. 39(3): 395-403, 2015
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SAPRIS-SERO study group publications
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1. Carrat, F., Lapidus, N., Ninove, L., Blanché, H., Rahib, D., Saba Villarroel, P.M., Touvier, M., Severi, G., Zins, M., Deleuze, J.F. and de Lamballerie, X., SAPRIS-SERO study group. 2021. Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France. Infection, pp.1-6.
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2. Deschasaux-Tanguy, M., Bourhis, L., Druesne-Pecollo, N., Esseddik, Y., Galan, P., Hercberg, S., de Lamballerie, X., Carrat, F., Touvier, M. and SAPRIS-SERO study group, Paris, France, 2021. Nutritional risk factors for SARS-CoV-2 infection: prospective study from the NutriNet-Santé cohort. European Journal of Public Health, 31(Supplement_3), pp.ckab165-243.
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3. Matta, J., Wiernik, E., Robineau, O., Carrat, F., Touvier, M., Severi, G., de Lamballerie, X., Blanché, H., Deleuze, J.F., Gouraud, C. and Hoertel, N., for the Santé, Pratiques, Relations et Inégalités Sociales en Population Générale Pendant la Crise COVID-19–Sérologie (SAPRIS-SERO) Study Group. 2021. Association of Self-reported COVID-19 Infection and SARS-CoV-2 Serology Test Results With Persistent Physical Symptoms Among French Adults During the COVID-19 Pandemic. JAMA internal medicine.
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4. Carrat, F., Villarroel, P.M.S., Lapidus, N., Fourié, T., Blanché, H., Dorival, C., Nicol, J., Deleuze, J.F. and Robineau, O. Heterogeneous SARS-CoV-2 humoral response after COVID-19 vaccination and/or infection in the general population. Scientific reports, 12(1), pp.1-10. 2022
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5. Carrat, F., Villarroel, P.M.S., Lapidus, N., Fourié, T., Blanché, H., Dorival, C., Nicol, J., Deleuze, J.F., Robineau, O., Touvier, M. and Severi, G., SAPRIS-SERO Study Group, Zins M., de Lamballerie X. Heterogeneous SARS-CoV-2 humoral response after COVID-19 vaccination and/or infection in the general population. Scientific reports, 12(1), pp.1-10. 2022
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6. Robineau, O., Zins, M., Touvier, M., Wiernik, E., Lemogne, C., de Lamballerie, X., Blanché, H., Deleuze, J.F., Villarroel, P.M.S., Dorival, C. and Nicol, J. Long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution. JAMA Network Open, 5(11), e2240985-e2240985. 2022.
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7. Ramillon, J., de Lamballerie, X., Robineau, O., Blanché, H., Severi, G., Touvier, M., Zins, M., Carrat, F. and Lapidus, N., 2023. Antibody response, associated symptoms and profile of patients presumably infected by SARS-CoV-2 with taste or smell disorders in the SAPRIS multicohort study. BMC Infectious Diseases, 23(1), pp.1-9.
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Books.
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Kuş Kitabı - Le livre des oiseaux
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Ayhan, N. and Charrel, R.N. Sandfly-Borne Viruses of Demonstrated / Relevant Medical Importance. In Vectors and Vector Borne Zoonotic Diseases. IntechOpen. 2018
Presentations.
Scientific Activities.
Mathematical Evolution Work-Shop
Nesin Mathematics School, 9-15 September 2013
Şirince, Izmir/ Turkey
Darwin Scholarship Program
Field Studies Council, 20-30 August 2013
Shrewsbury, London / United Kingdom
Fifth Nature Education in Kaçkar Mountain National Park
The Scientific and Technological Research Council of Turkey, 16-25 August 2010
Samsun / Turkey
Cernek Bird Ringing Station
Ondokuz Mayıs University, 04-11 September 2009
Artvin / Turkey
Ninth Bird Watching School
Gazi University, 07-08 March 2009
Ankara / Turkey
Underwater Science Camp
The Scientific and Technological Research Council of Turkey, 05-20 July 2008
Antalya/ Turkey
Collaborations.
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2019 Tehmina Bharucha
Doctor from Institute of Glycobiology, Department of Biochemistry, South Parks Road, Oxford / United Kingdom
23.09.2019 – 31.10.2019 -
2019 Carla Maia
Rearcher from Global Health and Tropical Medicine (GHMT), Universidade Nova de Lisboa, Lisboa / Portugal
11.02.2019 – 01.03.2019 -
2018 Cristina Cazan
PhD student from University of Cluj - Napoca / Romania
16.01.2018 – 15.03.2018 -
2017 Clara Munoz Hernandez
PhD student from University of Murcia / Spain
01.03.2017 – 04.05.2017 -
2016 Slavica Vaselek
PhD student from University of Novi-Sad / Serbia
22.09.2016 – 09.11.2016
Trained Students.
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2019-2021 Vincent Cicculli
PhD student from University of Corsica / France
September 2019-2021 -
2019-2021 Lison Laroche
PhD student from University of Montpellier / France
September 2019-2021 -
2018 Ani Bagramian
internship student from University of Claude Bernard Lyon 1 / France
03.01.2018 – 01.06.2018 -
2017 Kahina Bennai
internship student from M’hamed Bougara Boumerdes University / Algeria
03.06.2017 – 15.07.2017 -
2017 Kivanc Sevim
internship student from Hacettepe University / Turkey
27.06.2017 – 21.09.2017
Contact.
nazliayhann@gmail.com
- Aix Marseille University Faculty of Medicine,
- Department of Emergence of Viral Diseases, UMR190
- Marseille, FRANCE